Dr Liying Low MBChB (Hons), Ph.D, FRCOphth

Dr Liying Low

Department of Inflammation and Ageing
NIHR Clinical Lecturer in Ophthalmology
Specialty Registrar in Ophthalmology

Contact details

Address
Academic Unit of Ophthalmology
Institute of Inflammation and Ageing
Centre for Translational Inflammation Research
Birmingham and Midland Eye Centre
Dudley Road
Birmingham, B18 7QH

Dr Liying Low is an National Institute for Health and Care Research (NIHR)-funded Clinical Lecturer in Ophthalmology based at the University of Birmingham.

She was awarded the NIHR Academic Clinical Fellowship in Ophthalmology from 2013 to 2016. In 2016, she was successful in securing a Fight for Sight Clinical Fellowship to undertake her PhD project, investigating the clinical utility of genomic sequencing for ocular inflammatory and infectious diseases, supervised by Professors Saaeha Rauz, Nicholas J Loman, Philip I Murray and Dr Graham Wallace. In 2019, she completed her research fellowship at the University of Washington, Seattle, USA under the supervision of Professor Russell Van Gelder, to investigate the role of molecular sequencing for the rapid identification of causative pathogens in endophthalmitis.

She served as the Deputy Chair of the Ophthalmologists in Training Group (OTG) for the Royal College of Ophthalmologists and is currently a trainee representative on the NIHR UK-wide Ophthalmology Research Strategy Executive Board and the Sight Research UK Seed Award panel. 

Liying is actively involved in the clinical management, both medically and surgically, of patients with eye disease.

Qualifications

  • Fellow of the Royal College of Ophthalmologists (FRCOphth)
  • Ph.D – Clinical Utility of Genomic Sequencing for Ocular Inflammatory and Infectious Diseases
  • Royal College of Ophthalmologists Refraction Certificate (awarded the Elizabeth Hunt medal for highest mark)
  • United States Medical Licensing Examination (USMLE), ECFMG certified
  • MBChB (with Honours), Bachelor in Medicine and Bachelor in Surgery, University of Glasgow (Distinction for overall academic performance in final year medical degree, Student Selected Module 3 Excellence Award in Paediatric Ophthalmology)

Biography

Liying read Medicine at the University of Glasgow, graduating with Honours in 2011. Her interests in clinical research started early in her medical school years, undertaking electives to build upon her research skills as a research scholar (Duke University, USA, 2009), and her clinical skills through a Visiting Medical Student Clerkship Programme (Mayo Clinic, USA, 2010).

She furthered her medical training through the Academic Foundation Programme with the East of Scotland Deanery, in 2011, and undertook a rotation in academic ophthalmology, mentored by Professor Dame Carrie MacEwen. In recognition of her research work to improve the clinical management of ocular trauma, she received the Dundee Clinical Academic Track Discovery Travel Award in 2013.

She was successful in securing a National Institute for Health Research (NIHR) Academic Clinical Fellowship Award in 2013 and subsequently took up ophthalmology specialist training with the Health Education West Midlands School of Ophthalmology. In 2015, she received the Herefordshire Medical Society Junior Staff Prize for best medical case presentation. She was awarded the Elizabeth Hunt medal for attaining the highest mark in the Royal College of Ophthalmologists (RCOphth) Refraction Certificate.

She was awarded a Fight for Sight Clinical Fellowship in 2016 to undertake a PhD project, to explore the clinical utility of genomic sequencing in ocular inflammatory and infectious diseases. She received the Association for Research in Vision and Ophthalmology (ARVO) International Travel Grant 2018, which is awarded to “investigators whose research findings are considered to be of high interest to the vision and ophthalmology research community” for her abstract on the gut microbiome profile in patients with Behçet’s Disease.

In 2019, she completed a research fellowship at the University of Washington, Seattle, USA under the supervision of Professor Russell Van Gelder, to investigate the role of molecular sequencing for the rapid identification of causative pathogens in endophthalmitis. She was awarded the best academic presentation at the Midlands Ophthalmological Society Meeting in 2019. Following her maternity leave, she has been successful in securing an NIHR Clinical Lectureship in Ophthalmology (2020 – present). In 2021, she won the prestigious Founder’s Cup at the Oxford Ophthalmological Congress.

Liying has served in leadership roles at national and international committees - Deputy Chair of the Ophthalmologists in Training Group for the Royal College of Ophthalmologists (2018 – 2020), trainee representative on the NIHR UK-wide Ophthalmology Research Strategy Executive Board (2020 – present) and UK Council Member of the International Society for Behçet’s Disease.

She is a member of the Sight Research UK Seed Award panel involved in assessing research grant applications and awards (2022 – present).

Research

Research interests

  • Investigating the relationship between immune responses, host genotype, gut and peri/ocular microbiome profiles that may contribute to the clinical manifestations in ocular inflammatory disease.
  • Rapid identification of causative pathogens and their antimicrobial resistance genes in eye infections

Research themes

Gut Microbiome, Ocular Inflammation, Ocular Infection, Sequencing

Other activities

  • Sight Research UK Seed Award panel (2022 – present)
  • Deputy Chair of the OTG, Royal College of Ophthalmologists, 2018 - 2020
  • UK Council Member, International Society for Behçet’s Disease, 2016 - present
  • Steering committee on the West Midlands Deanery Ophthalmology Trainee Research Network, 2015 – present
  • Organising Committee of the OCULUS Fellowship of the Royal College of Ophthalmologists (FRCOphth) Part 2 revision course, 2015 – 2016.
  • Honorary Clinical Teacher, University of Dundee, 2011 – 2015
  • Public engagement work: Invited speaker, Keeping an eye on the gut – the role of the microbiome in eye health, for Café Scientifique, organised by the Birmingham Museums Trust, 2019

Publications

Low L, Nakamichi K, Akileswaran L, Lee CS, Lee AY, Moussa G, Murray PI, Wallace GR, Van Gelder RN, Rauz S. Deep metagenomic sequencing for endophthalmitis pathogen detection using a nanopore platform. Am J Ophthalmol. 2022 May 31:S0002-9394(22)00222-7. doi: 10.1016/j.ajo.2022.05.022. PMID: 35660421.

Low L, Suleiman K, Shamdas M, Bassilious K, Poonit N, Rossiter AE, Acharjee A, Loman N, Murray PI, Wallace GR, Rauz S. Gut Dysbiosis in Ocular Mucous Membrane Pemphigoid. Front Cell Infect Microbiol. 2022 Apr 14;12:780354. doi: 10.3389/fcimb.2022.780354. PMID: 35493740

Murad M, Low L, Davidson M, Murray PI, Rauz S, Wallace GR. Low density neutrophils are increased in patients with Behçet's disease but do not explain differences in neutrophil function. J Inflamm (Lond). 2022 Mar 31;19(1):5. doi: 10.1186/s12950-022-00302-1. PMID: 35361212

Mehmood N, Low L, Wallace GR. Behçet's Disease - Do microbiomes and genetics collaborate in pathogenesis?  Front Immunol. 2021 May 21;12:648341. doi: 10.3389/fimmu.2021.648341. PMID: 34093536

Low L*, Fuentes-Utrilla P, Hodson J, O’Neil JD, Rossiter AE, Begum G, Suleiman K, Murray PI, Wallace GR, Loman NJ*, Rauz S. Evaluation of full-length nanopore 16S sequencing for detection of pathogens in microbial keratitis.  West Midlands Collaborative Ophthalmology Network for Clinical Effectiveness. PeerJ. 2021 Feb 15. 9:e10778 doi: 10.7717/peerj.10778 PMID: 33628638

Low L*, Hodson J, Morris D, Desai P, MacEwen C. Socioeconomic deprivation and serious ocular trauma in Scotland: a national prospective study. Br J Ophthalmol. 2017 Mar 8. pii:bjophthalmol-2016-309875. doi: 10.1136/bjophthalmol-2016-309875 PMID: 28274942

Low L , Idriss SF, Anderson RH, Maynard CC, Wagner G, Hakacova N.The comparative relationships between locations of the papillary muscles and electrophysiologic QRS axis in patients with atrioventricular septal defect and common as opposed to separate orifices in the valve guarding the common atrioventricular junction. Cardiol Young 2016. Apr 18:1-6. [Epub ahead of print] PMID: 27087659

O’Colmain U, Low L, Gilmour C, MacEwen CJ. Vision screening in children – A retrospective study of social and demographic factors with regard to visual outcomes Br J Ophthalmol. pii: bjophthalmol-2015-307206. doi: 10.1136/bjophthalmol-2015-307206. PMID: 26598576.

Low L, Waqaar S, MacEwen CJ. Double vision. BMJ. 2015 Nov 18;351:h5385. doi: 10.1136/bmj.h5385. PMID: 26581615. (Featured on the front cover of BMJ November 2015)

Low L, Law JP, Hodson J, McAlpine R, O’Colmain U, MacEwen CJ. Impact of socioeconomic deprivation on the development of diabetic retinopathy: a large populationbased, cross-sectional & longitudinal study over 12 years in East of Scotland. BMJ Open. 2015 Apr 15;5(4):e007290. doi: 10.1136/bmjopen-2014-007290. PMID: 25877277

Low L, O'Colmain U, Ogston S, Macewen C. Accessibility of high-street optometry premises within Tayside. Br J Ophthalmol. 2013 Sep;97(9):1216-7. doi: 10.1136/bjophthalmol-2013-303471. PMID: 23775403

Heng SJ, Low L, MacKinnon JR, Lavy T, Dutton GN. Evaluation of the utility of hospital databases to provide data in assessing the quality of strabismus surgery. Scott Med J. 2013 May;58(2):104-8. doi: 10.1177/0036933013482641. PMID: 23728756

*Corresponding author

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