Dr Paul Harrison BSc, PhD, FRCPath

Paul Harrison

Institute of Inflammation and Ageing
Senior Lecturer

Contact details

Address
Institute of Inflammation and Ageing
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham
B15 2TT
UK

Paul Harrison is the Scar Free Foundation Senior Lecturer within the Institute of Inflammation and Ageing at the University of Birmingham in the UK. He is a Past- President of the British Society of Haemostasis & Thrombosis (BSHT) and a Past-chairman of the International Society of Thrombosis and Haemostasis (ISTH) Platelet Physiology Scientific and standardization committee. He has published over 180 papers and book chapters/reviews in his field. In 2010 Paul was featured as one of the top 100 healthcare scientists in the UK by the Department of Health.

Qualifications

  • Fellow of the Royal College of Pathologists (FRCPath)
  • Registered Clinical Scientist
  • PhD
  • BSc Biochemistry (Toxicology)

Biography

Paul Harrison is the Scar Free Foundation Senior Lecturer within the Institute of Inflammation and Ageing at the University of Birmingham. He is a Past-President of the British Society of Haemostasis and Thrombosis (BSHT), a Past-chairman of the International Society of Thrombosis and Haemostasis (ISTH) Platelet Physiology Scientific and standardization committee and co-editor in chief of the International Journal “Platelets”. He has published over 180 papers and book chapters/reviews. In 2010 Paul was featured as one of the top 100 healthcare scientists in the UK by the Department of Health.

Teaching

  • MBChB
    • Personal Mentor for Medical Students
    • Tutor for Infection, Immunology & Haematology (Year 2)
    • Lecturer for SP1 - Clinical Aspects of Immunology, Haematology & Immunity
  • MPharm
    • Lecturer and Tutor
  • BMedSc
    • Lecturer - Vascular Biology and Pathology (Year 1)
    • Lecturer - Immunity and Infection (Year 2)
    • Lecturer - Immunity and Inflammatory Disease (Year 3)
    • Lecturer - Integrative Physiology and Pharmacology (Year 3)

Postgraduate supervision

Paul Harrison is the Scar free Foundation Senior Lecturer within the Institute of Inflammation and Ageing. Dr Harrison is researching into the influence of traumatic injury and burns on the systemic inflammatory response with a particular focus on haemostatic and thrombotic parameters. He is also a member of the Birmingham platelet group.

Current PhD projects include :-
1) Measurement of preplatelets in inherited and acquired thrombocytopenia
2) Neutrophil Extracellular Traps in Thermal and Traumatic Injury
3) Measurement of extracellular vesicles in cardiovascular disease by a novel interferometric imaging method

If you are interesting in studying any of these subject areas please contact Dr Paul Harrison directly, or for any general doctoral research enquiries, please email mds-gradschool@contacts.bham.ac.uk.

For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings.

Research

Dr Harrison is researching into the influence of traumatic injury and burns on the systemic inflammatory response with a particular focus on haemostatic and thrombotic parameters. He is also a member of the Birmingham platelet group and the Genotyping and Phenotyping of Platelets Study (GAPP). His main interests are platelet biology, thrombopoeisis, platelet function testing, extracellular vesicles and regenerative medicine.

Other activities

  • Past-President of the British Society for Haemostasis and Thrombosis
  • Past-Chairman of the Platelet Physiology Scientific and Standardization committee of the International Society of Thrombosis and Haemostasis
  • Board member of the International Council for Standardization in Haematology (ICSH)
  • Co-editor in chief of Platelets (2015-2022) (Impact factor 3.106) 
  • Member of the editorial board for the Journal of Thrombosis and Haemostasis
  • Winner of 2009 Sysmex Outstanding Science Award, Istanbul, May 2009
  • Featured in the publication “Extraordinary You” – as one of top 100 healthcare scientists within the UK by the Department of Health, 2009/2010

Publications

Recent publications

Article

Montague, S, Price, J, Pennycott, K, Pavey, N, Slater, E, Thirlwell, I, Kemble, S, Monteiro, C, Redmond-Motteram, L, Lawson, N, Reynolds, K, Fratter, C, Bignell, P, Groenheide, A, Huskens, D, Laat, BD, Pike, J, Poulter, N, Thomas, S, Lowe, G, Lancashire, J, Harrison, P & Morgan, N 2024, 'Comprehensive functional characterisation of a novel ANO6 variant in a new patient with Scott Syndrome', Journal of Thrombosis and Haemostasis. https://doi.org/10.1016/j.jtha.2024.02.021

Asiri, A, Hazeldine, J, Moiemen, N & Harrison, P 2024, 'IL-8 Induces Neutrophil Extracellular Trap Formation in Severe Thermal Injury', International Journal of Molecular Sciences, vol. 25, no. 13, 7216. https://doi.org/10.3390/ijms25137216

Chen, Y-Y, Sullivan, J, Hanley, S, Price, J, Tariq, M, McIlvenna, LC, Whitham, M, Sharma-Oates, A, Harrison, P, Lord, J & Hazeldine, J 2024, 'Impact of Senescent Cell-Derived Extracellular Vesicles on Innate Immune Cell Function', Advanced Biology. https://doi.org/10.1002/adbi.202400265

Asiri, A, Price, J, Hazeldine, J, McGee, K, Veiga Sardeli, A, Chen, Y-Y, Sullivan, J, Moiemen, N & Harrison, P 2024, 'Measurement of platelet thrombus formation in patients following severe thermal injury', Platelets. https://doi.org/10.1080/09537104.2024.2420952

Welsh, JA, Goberdhan, DCI, O'Driscoll, L, Buzas, EI, Blenkiron, C, Bussolati, B, Cai, H, Di Vizio, D, Driedonks, TAP, Erdbrügger, U, Falcon‐Perez, JM, Fu, QL, Hill, AF, Lenassi, M, Lim, SK, Mahoney, MG, Mohanty, S, Möller, A, Nieuwland, R, Ochiya, T, Sahoo, S, Torrecilhas, AC, Zheng, L, Zijlstra, A, Abuelreich, S, Bagabas, R, Bergese, P, Bridges, EM, Brucale, M, Burger, D, Carney, RP, Cocucci, E, Crescitelli, R, Hanser, E, Harris, AL, Haughey, NJ, Hendrix, A, Ivanov, AR, Jovanovic‐Talisman, T, Kruh‐Garcia, NA, Ku'ulei‐lyn Faustino, V, Kyburz, D, Lässer, C, Lennon, KM, Lötvall, J, Maddox, AL, Martens‐Uzunova, ES, Mizenko, RR, Newman, LA, Théry, C, MISEV Organizing Committee., Harrison, P & Witwer, KW 2024, 'Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches', Journal of Extracellular Vesicles, vol. 13, no. 2, e12404. https://doi.org/10.1002/jev2.12404

Tullie, S, Nicholson, T, Bishop, J, McGee, K, Asiri, A, Sullivan, J, Chen, Y-Y, Veiga Sardeli, A, Belli, T, Harrison, P, Moiemen, N, Lord, J & Hazeldine, J 2024, 'Severe thermal and major traumatic injury results in elevated plasma concentrations of total heme that are associated with poor clinical outcomes and systemic immune suppression', Frontiers in immunology, vol. 15, 1416820. https://doi.org/10.3389/fimmu.2024.1416820

Alenazy, F, Harbi, M, Kavanagh, D, Price, J, Brady, P, Hargreaves, O, Harrison, P, Slater, A, Tiwari, A, Nicolson, P, Connolly, D, Kirchhof, P, Kalia, N, Jandrot-Perrus, M, Mangin, PH, Watson, S & Thomas, MR 2023, 'Amplified inhibition of atherosclerotic plaque-induced platelet activation by glenzocimab with dual antiplatelet therapy JTH', Journal of thrombosis and haemostasis : JTH, vol. 21, no. 11, pp. 3236-3251. https://doi.org/10.1016/j.jtha.2023.07.018

Price, J, Hazeldine, J, Hisada, Y, Bae-Jump, V, Luther, T, Mackman, N & Harrison, P 2023, 'Detection of tissue factor positive extracellular vesicles using the ExoView R100 System', Research and Practice in Thrombosis and Haemostasis, vol. 7, no. 4, 13. https://doi.org/10.1016/j.rpth.2023.100177

Kemble, S, Dalby, A, Lowe, G, Nicolson, P, Watson, S, Senis, Y, Thomas, S & Harrison, P 2022, 'Analysis of preplatelets and their barbell platelet derivatives by imaging flow cytometry', Blood Advances, vol. 6, no. 9, pp. 2932–2946. https://doi.org/10.1182/bloodadvances.2021006073

Mahida, RY, Price, J, Lugg, ST, Li, H, Parekh, D, Scott, A, Harrison, P, Matthay, MA & Thickett, DR 2022, 'CD14-positive extracellular vesicles in bronchoalveolar lavage fluid as a new biomarker of acute respiratory distress syndrome', American journal of physiology. Lung cellular and molecular physiology, vol. 322, no. 4, pp. L617-L624. https://doi.org/10.1152/ajplung.00052.2022

Mezzano, D, Harrison, P, Andrew L. Frelinger, III, Mumford, AD, Noris, P, Lordkipanidzé, M & Gresele, P 2022, 'Expert opinion on the use of platelet secretion assay for the diagnosis of inherited platelet function disorders: communication from the ISTH SSC Subcommittee on platelet physiology', Journal of Thrombosis and Haemostasis, vol. 20, no. 9, pp. 2127-2135. https://doi.org/10.1111/jth.15781

Harrison, P, Price, J, Didembourg, M, Johnstone, A, Baldwin, S, Veronneau, M, Baertlein, D, Shi, X & Machin, S 2022, 'Feasibility of a mean platelet volume standard: an international council for standardization in hematology (ICSH) inter-laboratory study', Platelets, vol. 33, no. 8, pp. 1-9. https://doi.org/10.1080/09537104.2022.2060956

PATH-2 trial group 2022, 'Platelet-rich plasma injection for acute Achilles tendon rupture: two-year follow-up of the PATH-2 randomized, placebo-controlled, superiority trial', Bone and Joint Journal, vol. 104-B, no. 11, pp. 1256-1265. https://doi.org/10.1302/0301-620X.104B11.BJJ-2022-0653.R1

Colicchia, M, Schrottmaier, WC, Perrella, G, Reyat, JS, Begum, J, Slater, A, Price, J, Clark, JC, Zhi, Z, Simpson, M, Bourne, J, Poulter, NS, Khan, AO, Nicolson, PLR, Pugh, MR, Harrison, P, Iqbal, AJ, Rainger, GE, Watson, SP, Thomas, MR, Mutch, NJ, Assinger, A & Rayes, J 2022, 'S100A8/A9 drives the formation of procoagulant platelets through GPIbα', Blood. https://doi.org/10.1182/blood.2021014966

Review article

Couch, Y, Buzas, E, Di Vizio, D, Gho, YS, Harrison, P, Hill, A, Lötvall , J, Raposo, G, Stahl , P, Théry , C, Witwer, K & Carter, D 2021, 'A brief history of nearly EV-erything – the rise and rise of extracellular vesicles', Journal of Extracellular Vesicles, vol. 10, no. 14, e12144. https://doi.org/10.1002/jev2.12144

View all publications in research portal