Professor Adam Cunningham

• PhD – The detection, epidemiology and immunobiology of Chlamydia pneumoniae, 1995
• BSc (Hons) – 2.1 in Pathobiology, 1991

Cunningham graduated from The University of Reading in 1991 with a 2.1 in Pathobiology. He was awarded his PhD in Southampton in 1995 on “The detection, epidemiology and immunobiology of Chlamydia pneumoniae”, supervised by Professor Mike Ward.

His first post-doctoral position, as part of the (then) Glaxo Wellcome Action TB initiative, examined how Mycobacterium tuberculosis adapted to changes in oxygen tension, a common feature of granulomas and associated with conversion of tubercle bacilli to a persisting state. In 1999 he undertook a post-doctoral position with Prof. Ian MacLennan examining how antibody responses develop and are regulated. During this time Cunningham incorporated the use of Salmonella and its component antigens into this work. This led to his first independent position in Birmingham in January 2005 as a tenure-track RCUK Roberts Academic Fellow studying how immune responses develop to pathogens and vaccines.

He was made Senior Research Fellow in October 2009, Senior Lecturer in June 2010, Reader in October 2010 and Professor of Functional Immunity in August 2011.

Cunningham teaches on the MBChB, BMedSc and postgraduate courses and also teaches qualified medics in various aspects of immunology and research. He has also successfully supervised PhD students in immunology and infection and is interested in hearing from individuals who wish to pursue a PhD.

• Medicine and Surgery MBChB
• Medical Science BMedSc

Adam supervises doctoral research students in the areas of adaptive immunity, vaccine function, immunomodulation and immunity to infection.

If you are interesting in studying any of these subject areas please contact Professor Adam Cunningham directly, or for any general doctoral research enquiries, please email mds-gradschool@contacts.bham.ac.uk.

For a full list of available Doctoral Research opportunities, please visit our Doctoral Research programme listings.

Themes

B cells, T cells, generation and maintenance of adaptive responses, infection, vaccination, immune homeostasis, immune modulation

Lay summary

Their work aims to understand how infection changes who we are as individuals. Their work has a particular focus on how infection can educate the immune system and the specific elements and cells of the immune system that respond to pathogens. An exciting consequence of this work is that by comparing how they react to the whole pathogen or to individual components of the pathogen thry can generate new vaccines to infections and new treatments to infectious and non-infectious diseases.

Overview

Their research uses in vivo models of infection to study how infection and vaccination modifies immune homeostasis, with a particular emphasis on adaptive immunity. Relating these changes to bacterial clearance helps identify how infections are controlled and how vaccines function. Furthermore, understanding the relationship between host and pathogen helps identify novel approaches to exploit bacteria and their components as prophylactics and therapeutics in infectious and non-infectious diseases (Fig. 1).

Examples of current themes ongoing in the laboratory include:

1. The development of vaccines against non-typhoidal Salmonella and the potential of B1b cells as targets for vaccination
2. How T and B cell responses are regulated after infection and vaccination
3. How lymphopoiesis is regulated in the thymus and bone marrow during infection
4. How bacteria and their components immunomodulate the host during infectious and non-infectious disease
5. How multiple and co-infections impact upon host homeostasis and immune function
6. How dormant tuberculosis infections in humans are maintained

Such investigations require studies of immune homeostasis in multiple anatomical locations concurrently, the different cellular subsets involved and the kinetics of these events (Fig. 2)

Though this work is performed primarily in the context of infection and vaccination, with a particular focus on adaptive immunity and its direction by the innate immune system, the principles allow us to investigate how non-infectious disease impacts on the host.

Their work has shown that the immune system responds differently to the same antigen when presented in different immunological contexts and in different anatomical compartments. This is important since it means they can modify the response to an antigen or promote a particular host function simply by altering how they deliver antigen to the immune system. This capacity to modulate the host response to a pathogen or a component of a pathogen or a vaccine underlies our translational work (see publications). Lastly, using this knowledge they can exploit their findings to maintain and improve health as we age through directing and stimulating beneficial, long-term immune responses. Collectively, their work therefore helps understand how they can improve immunity to infectious and non-infectious disease.

• Reviewer for a number of high-impact, internationally-competitive, journals and funding agencies in the UK and abroad
• Panel member of the Royal Society Joint International Projects committee
• Organized a number of national and international meetings on microbiology, infection and immunology