Professor Karla Hemming PhD

Professor Karla Hemming

Department of Applied Health Sciences
Professor of Biostatistics

Contact details

Address
Public Health, Epidemiology and Biostatistics
Institute of Applied Health Research
College of Medical and Dental Sciences
University of Birmingham
Edgbaston
Birmingham, B15 2TT

Karla is a Professor of Biostatistics at the Institute of Applied Health Research, University of Birmingham, UK. Karla’s research interests include how to design cluster and stepped-wedge trials so as to maximise their statistical efficiency and minimise their risk of bias; how to model time and treatment effect heterogeneity in longitudinal cluster trials; and the ethical issues surrounding these pragmatic trial designs, such as ethical oversight and consent. Karla has recently led the CONSORT extension for the stepped-wedge cluster randomised trial.

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Teaching

Teaching Programmes

MBChB Year 2 Integrated Problems (statistics)

Master in Public Health (ESRM and Advanced Statistics)

Postgraduate supervision

Karla Hemming's research interests include perinatal epidemiology, meta-analysis, missing data and cluster trials. She has conducted and published research in a number of areas, including:

Prescribing errors in electronic prescribing
Large-scale organisational intervention to improve patient safety
Bayesian sensitivity models for missing covariates in the analysis of survival data
Meta-regression with partial information

Publications

Recent publications

Article

Kudrna, L, Yates, J, Alidu, L, Hemming, K, Quinn, L, Schmidtke, KA, Jones, J, Al-Khudairy, L, Jolly, K, Bird, P, Campbell, N, Bharatan, I, Latuszynska, A, Currie, G & Lilford, R 2025, 'A Mixed-Methods Cluster Randomised Waitlist-Controlled Trial of a Goal-Based Behaviour Change Intervention Implemented in Workplaces', International Journal of Environmental Research and Public Health, vol. 22, no. 3, 398. https://doi.org/10.3390/ijerph22030398

MacArthur, C, Bick, D, Salmon, V, Jones, E, Hay-smith, J, Bishop, J, Gkini, E, Hemming, K, Webb, S, Pearson, M, Coleman, T, Terry, R, Edwards, E, Frawley, H, Oborn, E & Dean, S 2025, 'Antenatal pelvic floor muscle exercise intervention led by midwives in England to reduce postnatal urinary incontinence: APPEAL feasibility and pilot randomised controlled cluster trial', BMJ open, vol. 15, no. 1, e091248. https://doi.org/10.1136/bmjopen-2024-091248

Dickinson-Craig, E, Turbat, T, Hemming, K, Pope, F, Bartington, S, Anjaa, S, Davaa, S, Day, R, Boldbaatar, D, Ochir, C, Warburton, D, Thomas, GN, Badarch, J & Manaseki-Holland, S 2025, 'Improving Air Quality and Childhood Respiratory Health in Mongolia: The Impact of the Raw Coal Ban and COVID-19 Restrictions—An Interrupted Time-Series Analysis', Atmosphere, vol. 16, no. 1, 46. https://doi.org/10.3390/atmos16010046

McKenzie, JE, Taljaard, M, Hemming, K, Arnup, SJ, Giraudeau, B, Eldridge, S, Hooper, R, Kahan, BC, Li, T, Moher, D, Turner, EL, Grimshaw, JM & Forbes, AB 2025, 'Reporting of cluster randomised crossover trials: extension of the CONSORT 2010 statement with explanation and elaboration', BMJ (Clinical research ed.), vol. 388, e080472. https://doi.org/10.1136/bmj-2024-080472

Williams, EV, Goranitis, I, Oppong, R, Perry, SJ, Devall, AJ, Martin, JT, Mammoliti, K-M, Beeson, LE, Sindhu, KN, Galadanci, H, Al-beity, FA, Qureshi, Z, Hofmeyr, GJ, Moran, N, Fawcus, S, Mandondo, S, Middleton, L, Hemming, K, Oladapo, OT, Gallos, ID, Coomarasamy, A & Roberts, TE 2024, 'A cost-effectiveness analysis of early detection and bundled treatment of postpartum haemorrhage alongside the E-MOTIVE trial', Nature Medicine. https://doi.org/10.1038/s41591-024-03069-5

Schmidtke, KA, Kudrna, L, Quinn, L, Bird, P, Hemming, K, Venable, Z & Lilford, R 2024, 'Cluster randomised evaluation of a training intervention to increase the use of statistical process control charts for hospitals in England: making data count', BMJ Quality & Safety. https://doi.org/10.1136/bmjqs-2024-017094

Hemming, K, Kudrna, L, Watson, S, Taljaard, M, Greenfield, S, Goulao, B & Lilford, R 2024, 'Interpretation of statistical findings in randomised trials: a survey of statisticians using thematic analysis of open-ended questions', BMC Medical Research Methodology, vol. 24, no. 1, 256. https://doi.org/10.1186/s12874-024-02366-4

Hemming, K, Thompson, JY, Taljaard, M, Watson, SI, Kasza, J, Thompson, JA, Kahan, BC & Copas, AJ 2024, 'Re-analysis of data from cluster randomised trials to explore the impact of model choice on estimates of odds ratios: study protocol', Trials, vol. 25, no. 1, 818. https://doi.org/10.1186/s13063-024-08653-1

Quinn, L, Martin, J, Asamane, E, Manaseki-Holland, S, Lilford, RJ, Traore, L, Thompson, J, Watson, SI & Hemming, K 2024, 'Statistical analysis plan for cluster randomised trial to evaluate a community-level complementary food safety and hygiene and nutrition intervention in Mali: the MaaCiwara study', Trials, vol. 25, no. 1, 483. https://doi.org/10.1186/s13063-024-08328-x

Hemming, K, Copas, A, Forbes, A & Kasza, J 2024, 'What type of cluster randomized trial for which setting?', Journal of epidemiology and population health, vol. 72, no. 1, 202195. https://doi.org/10.1016/j.jeph.2024.202195

Hemming, K, Melo, P, Luo, R, Taljaard, M & Coomarasamy, A 2023, 'A re‐analysis of 150 women's health trials to investigate how the Bayesian approach may offer a solution to the misinterpretation of statistical findings', BJOG: An International Journal of Obstetrics & Gynaecology. https://doi.org/10.1111/1471-0528.17570

Review article

Thompson, J, Watson, SI, Middleton, L & Hemming, K 2025, 'Estimating relative risks and risk differences in randomised controlled trials: a systematic review of current practice', Trials, vol. 26, 1. https://doi.org/10.1186/s13063-024-08690-w

Hemming, K, Thompson, J, Hooper, RL, Ukoumunne, OC, Li, F, Caille, A, Kahan, BC, Leyrat, C, Grayling, MJ, Mohammed, NI, Thompson, JA, Giraudeau, B, Turner, EL, Watson, S, Goulão, B, Kasza, J, Forbes, AB, Copas, AJ & Taljaard, M 2025, 'Guidelines for the content of statistical analysis plans in clinical trials: protocol for an extension to cluster randomized trials', Trials, vol. 26, 72. https://doi.org/10.1186/s13063-025-08756-3

Thompson, JY, Shaw, J, Watson, S, Wang, Y, Robinson, C, Taljaard, M & Hemming, K 2025, 'Review of the quality of reporting of statistical analysis plans for cluster randomized trials', Journal of Clinical Epidemiology. https://doi.org/10.1016/j.jclinepi.2025.111726

Goldstein, CE, Marouf, Y, Johri, M, Shaw, JF, Sergeant, A, Nicholls, SG, Althabe, F, Ferrand, RA, van der Graaf, R, Hemming, K, Mbuagbaw, L, Treweek, S, Welch, VA, Weijer, C & Taljaard, M 2024, 'Systematic scoping review of cluster randomised trials conducted exclusively in low-income and middle-income countries between 2017 and 2022', BMJ open, vol. 14, no. 9, e087724. https://doi.org/10.1136/bmjopen-2024-087724

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