• Arlt et al (2017) ‘Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism’ JCI Insight DOI: 10.1172/jci.insight.93136
• The report can be found at https://insight.jci.org/articles/view/93136
• The researchers used highly sensitive mass spectrometry to analyse aldosterone and cortisol levels in patients’ urine samples.
• The study showed that waist circumference, insulin, diabetes risk and cholesterol were associated with cortisol but not with aldosterone production.
• The researchers found that in the adrenals of those patients who underwent surgical removal of one of their adrenals, overproduction of cortisol was associated with an increased content of the cortisol-producing enzyme CYP11B1.
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